Recurrent tuberculosis in Denmark: relapse vs. re-infection.
Int J Tuberc Lung Dis
; 14(4): 447-53, 2010 Apr.
Article
in En
| MEDLINE
| ID: mdl-20202303
ABSTRACT
SETTING:
Denmark, a country with a low-incidence of tuberculosis (TB).OBJECTIVE:
To analyse the proportion of relapse vs. re-infection and to compare selected characteristics between the two subgroups.DESIGN:
A population-based cohort study. All 4154 Mycobacterium tuberculosis isolates from patients in Denmark genotyped by insertion sequence 6110 restriction fragment length polymorphism were followed for recurrent TB over 13.5 years. Recurrent cases were classified as relapse or re-infection by genotype patterns in initial and serial disease episodes.RESULTS:
Recurrent TB was found in 73 (1.8%) cases. Identical M. tuberculosis genotypes in initial and serial episodes were found in 54 (1.3%), indicating relapse, whereas different genotypes, representing re-infection, were found in 19 (0.5%) cases. Cavitary TB in the initial episode was significantly associated with relapse (OR 4.6, 95%CI 1.1-26.9) compared to re-infection.CONCLUSION:
The rate of recurrent TB is low in Denmark. Comparing selected characteristics between the relapse and re-infection subgroups revealed that only the presence of cavitary disease was associated with relapse. Although recurrent TB was rarely due to re-infection, the risk of re-infection increased with time.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tuberculosis
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Int J Tuberc Lung Dis
Year:
2010
Type:
Article
Affiliation country:
Denmark