Phosphoramidates of 2'-beta-D-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism.

Mehellou, Youcef; Valente, Rocco; Mottram, Huw; Walsby, Elisabeth; Mills, Kenneth I; Balzarini, Jan; McGuigan, Christopher

Mehellou, Youcef; Valente, Rocco; Mottram, Huw; Walsby, Elisabeth; Mills, Kenneth I; Balzarini, Jan; McGuigan, Christopher.

Affiliation

Mehellou Y; Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK.

Bioorg Med Chem ; 18(7): 2439-46, 2010 Apr 01.

Article in En | MEDLINE | ID: mdl-20299228

Subject(s)

Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Antiviral Agents/chemical synthesis; Antiviral Agents/pharmacology; Arabinofuranosyluracil/chemical synthesis; Arabinofuranosyluracil/pharmacology; Prodrugs/chemical synthesis; Prodrugs/pharmacology; Animals; Antineoplastic Agents/pharmacokinetics; Antiviral Agents/pharmacokinetics; Arabinofuranosyluracil/pharmacokinetics; Cathepsin A/antagonists & inhibitors; Cathepsin A/metabolism; Cell Line, Tumor; Chromatography, Thin Layer; Drug Design; Esterases/antagonists & inhibitors; Humans; Indicators and Reagents; Liver/drug effects; Liver/enzymology; Lymphocytes/drug effects; Magnetic Resonance Spectroscopy; Models, Molecular; Nerve Tissue Proteins/antagonists & inhibitors; Prodrugs/pharmacokinetics; Structure-Activity Relationship; Swine; Viruses/drug effects

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Arabinofuranosyluracil / Prodrugs / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: United kingdom

Fulltext

XML

PubMed Links

Search on Google