Pharmacological profile and antiparkinsonian properties of the novel nociceptin/orphanin FQ receptor antagonist 1-[1-cyclooctylmethyl-5-(1-hydroxy-1-methyl-ethyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-3-ethyl-1,3-dihydro-benzoimidazol-2-one (GF-4).

Volta, Mattia; Marti, Matteo; McDonald, John; Molinari, Stefano; Camarda, Valeria; Pelà, Michela; Trapella, Claudio; Morari, Michele

Volta, Mattia; Marti, Matteo; McDonald, John; Molinari, Stefano; Camarda, Valeria; Pelà, Michela; Trapella, Claudio; Morari, Michele.

Affiliation

Volta M; Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara, Ferrara Italy.

Peptides ; 31(6): 1194-204, 2010 Jun.

Article in En | MEDLINE | ID: mdl-20307605

Subject(s)

Antiparkinson Agents/pharmacology; Benzimidazoles/pharmacology; Cyclooctanes/pharmacology; Receptors, Opioid/drug effects; Animals; Behavior, Animal/drug effects; CHO Cells; Cricetinae; Cricetulus; Male; Mice; Mice, Knockout; Motor Activity/drug effects; Oxidopamine/toxicity; Piperidines/pharmacology; Rats; Rats, Sprague-Dawley; Nociceptin Receptor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Receptors, Opioid / Cyclooctanes / Antiparkinson Agents Limits: Animals Language: En Journal: Peptides Year: 2010 Type: Article

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