Direct HPLC enantioseparation of omeprazole and its chiral impurities: application to the determination of enantiomeric purity of esomeprazole magnesium trihydrate.

Zanitti, Leo; Ferretti, Rosella; Gallinella, Bruno; La Torre, Francesco; Sanna, Maria Luisa; Mosca, Antonina; Cirilli, Roberto

Zanitti, Leo; Ferretti, Rosella; Gallinella, Bruno; La Torre, Francesco; Sanna, Maria Luisa; Mosca, Antonina; Cirilli, Roberto.

Affiliation

Zanitti L; Istituto Superiore di Sanità, Dipartimento del Farmaco, Viale Regina Elena 299, I-00161 Rome, Italy.

J Pharm Biomed Anal ; 52(5): 665-71, 2010 Sep 05.

Article in En | MEDLINE | ID: mdl-20338705

Subject(s)

Chromatography, High Pressure Liquid/methods; Omeprazole/isolation & purification; Circular Dichroism; Esomeprazole; Limit of Detection; Omeprazole/chemistry; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet; Stereoisomerism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Omeprazole / Chromatography, High Pressure Liquid Language: En Journal: J Pharm Biomed Anal Year: 2010 Type: Article Affiliation country: Italy

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