N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor.

McHugh, Douglas; Hu, Sherry S J; Rimmerman, Neta; Juknat, Ana; Vogel, Zvi; Walker, J Michael; Bradshaw, Heather B

McHugh, Douglas; Hu, Sherry S J; Rimmerman, Neta; Juknat, Ana; Vogel, Zvi; Walker, J Michael; Bradshaw, Heather B.

Affiliation

McHugh D; The Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA.

BMC Neurosci ; 11: 44, 2010 Mar 26.

Article in En | MEDLINE | ID: mdl-20346144

Subject(s)

Arachidonic Acids/metabolism; Cell Movement/immunology; Glycine/analogs & derivatives; Microglia/metabolism; Receptors, Cannabinoid/metabolism; Receptors, G-Protein-Coupled/metabolism; Animals; Animals, Newborn; Arachidonic Acids/pharmacology; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators/pharmacology; Cell Line, Transformed; Cell Movement/drug effects; Chemotaxis/drug effects; Chemotaxis/physiology; Glycine/metabolism; Glycine/pharmacology; Humans; Immunologic Surveillance/drug effects; Immunologic Surveillance/physiology; Mice; Mice, Inbred C57BL; Microglia/drug effects; Microglia/immunology; Receptors, G-Protein-Coupled/agonists; Resorcinols/metabolism; Resorcinols/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Movement / Arachidonic Acids / Microglia / Receptors, G-Protein-Coupled / Receptors, Cannabinoid / Glycine Limits: Animals / Humans Language: En Journal: BMC Neurosci Journal subject: NEUROLOGIA Year: 2010 Type: Article Affiliation country: United States

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