Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.

Schmid, Daphné A; Irving, Melita B; Posevitz, Vilmos; Hebeisen, Michael; Posevitz-Fejfar, Anita; Sarria, J-C Floyd; Gomez-Eerland, Raquel; Thome, Margot; Schumacher, Ton N M; Romero, Pedro; Speiser, Daniel E; Zoete, Vincent; Michielin, Olivier; Rufer, Nathalie

Schmid, Daphné A; Irving, Melita B; Posevitz, Vilmos; Hebeisen, Michael; Posevitz-Fejfar, Anita; Sarria, J-C Floyd; Gomez-Eerland, Raquel; Thome, Margot; Schumacher, Ton N M; Romero, Pedro; Speiser, Daniel E; Zoete, Vincent; Michielin, Olivier; Rufer, Nathalie.

Affiliation

Schmid DA; Multidisciplinary Oncology Center, Lausanne University Hospital, Switzerland.

J Immunol ; 184(9): 4936-46, 2010 May 01.

Article in En | MEDLINE | ID: mdl-20351194

Subject(s)

CD8-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/metabolism; Cytotoxicity, Immunologic; Neoplasm Proteins/metabolism; Peptide Fragments/metabolism; Receptors, Antigen, T-Cell, alpha-beta/metabolism; Antigens, Neoplasm/genetics; Antigens, Neoplasm/immunology; Antigens, Neoplasm/metabolism; Cell Adhesion/genetics; Cell Adhesion/immunology; Cell Line; Cell Line, Transformed; Cell Line, Tumor; Cells, Cultured; Cytotoxicity, Immunologic/genetics; HLA-A Antigens/genetics; HLA-A Antigens/immunology; HLA-A Antigens/metabolism; HLA-A2 Antigen; Humans; Membrane Proteins/genetics; Membrane Proteins/immunology; Membrane Proteins/metabolism; Neoplasm Proteins/genetics; Peptide Fragments/genetics; Protein Binding/genetics; Protein Binding/immunology; Receptors, Antigen, T-Cell, alpha-beta/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Receptors, Antigen, T-Cell, alpha-beta / CD8-Positive T-Lymphocytes / Cytotoxicity, Immunologic / Neoplasm Proteins Limits: Humans Language: En Journal: J Immunol Year: 2010 Type: Article Affiliation country: Switzerland

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