Pharmacokinetic/pharmacodynamic modeling of biomarker response to sunitinib in healthy volunteers.

Lindauer, A; Di Gion, P; Kanefendt, F; Tomalik-Scharte, D; Kinzig, M; Rodamer, M; Dodos, F; Sörgel, F; Fuhr, U; Jaehde, U

Lindauer, A; Di Gion, P; Kanefendt, F; Tomalik-Scharte, D; Kinzig, M; Rodamer, M; Dodos, F; Sörgel, F; Fuhr, U; Jaehde, U.

Affiliation

Lindauer A; Department of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, Bonn, Germany.

Clin Pharmacol Ther ; 87(5): 601-8, 2010 May.

Article in En | MEDLINE | ID: mdl-20376000

Subject(s)

Blood Pressure/drug effects; Indoles/pharmacology; Indoles/pharmacokinetics; Models, Biological; Pyrroles/pharmacology; Pyrroles/pharmacokinetics; Adult; Biomarkers/blood; Biomarkers/metabolism; Blood Pressure/physiology; Female; Humans; Indoles/blood; Male; Middle Aged; Protein Kinase Inhibitors/blood; Protein Kinase Inhibitors/pharmacokinetics; Protein Kinase Inhibitors/pharmacology; Protein-Tyrosine Kinases/antagonists & inhibitors; Pyrroles/blood; Sunitinib; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Blood Pressure / Indoles / Models, Biological Type of study: Prognostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Clin Pharmacol Ther Year: 2010 Type: Article Affiliation country: Germany

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