Pharmacokinetic-pharmacodynamic-model-guided doripenem dosing in critically ill patients.

Samtani, Mahesh N; Flamm, Robert; Kaniga, Koné; Nandy, Partha

Samtani, Mahesh N; Flamm, Robert; Kaniga, Koné; Nandy, Partha.

Affiliation

Samtani MN; Clinical Pharmacology, Advanced PK/PD Modeling and Simulation, Johnson & Johnson Pharmaceutical Research & Development, LLC, Titusville, NJ 08560, USA.

Antimicrob Agents Chemother ; 54(6): 2360-4, 2010 Jun.

Article in En | MEDLINE | ID: mdl-20385857

Subject(s)

Anti-Bacterial Agents/pharmacology; Anti-Bacterial Agents/pharmacokinetics; Carbapenems/pharmacology; Carbapenems/pharmacokinetics; Gram-Negative Bacterial Infections/drug therapy; Gram-Negative Bacterial Infections/metabolism; Models, Biological; Anti-Bacterial Agents/administration & dosage; Carbapenems/administration & dosage; Creatinine/metabolism; Critical Illness; Doripenem; Drug Administration Schedule; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacterial Infections/microbiology; Gram-Positive Bacterial Infections/drug therapy; Gram-Positive Bacterial Infections/metabolism; Gram-Positive Bacterial Infections/microbiology; Humans; Infusions, Intravenous; Microbial Sensitivity Tests; Monte Carlo Method

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbapenems / Gram-Negative Bacterial Infections / Anti-Bacterial Agents / Models, Biological Type of study: Health_economic_evaluation Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2010 Type: Article Affiliation country: United States

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