Critical role of cytosolic phospholipase A2{alpha} in bronchial mucus hypersecretion in CFTR-deficient mice.

Dif, F; Wu, Y-Z; Burgel, P-R; Ollero, M; Leduc, D; Aarbiou, J; Borot, F; Garcia-Verdugo, I; Martin, C; Chignard, M; Israel-Biet, D; Kita, Y; Scholte, B J; Touqui, L

Dif, F; Wu, Y-Z; Burgel, P-R; Ollero, M; Leduc, D; Aarbiou, J; Borot, F; Garcia-Verdugo, I; Martin, C; Chignard, M; Israel-Biet, D; Kita, Y; Scholte, B J; Touqui, L.

Affiliation

Dif F; Unité de Défense Innée et Inflammation, Inserm, Paris, France.

Eur Respir J ; 36(5): 1120-30, 2010 Nov.

Article in En | MEDLINE | ID: mdl-20413542

Subject(s)

Bronchi/metabolism; Cystic Fibrosis Transmembrane Conductance Regulator/genetics; Group IV Phospholipases A2/genetics; Group IV Phospholipases A2/metabolism; Mucin 5AC/metabolism; Mucus/metabolism; Animals; Arachidonic Acid/metabolism; Bronchi/cytology; Cell Line; Chlorides/metabolism; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism; Cytosol/metabolism; Disease Models, Animal; Humans; Lipopolysaccharides/pharmacology; Mice; Mice, Inbred C57BL; Mice, Inbred CFTR; Mucin 5AC/genetics; RNA, Small Interfering; Respiratory Mucosa/cytology; Respiratory Mucosa/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bronchi / Cystic Fibrosis Transmembrane Conductance Regulator / Group IV Phospholipases A2 / Mucin 5AC / Mucus Limits: Animals / Humans Language: En Journal: Eur Respir J Year: 2010 Type: Article Affiliation country: France

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