Neurite-like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APP.

Hughes, Mary; Snetkov, Vladimir; Rose, Ruth-Sarah; Trousil, Sebastian; Mermoud, Jacqueline E; Dingwall, Colin

Hughes, Mary; Snetkov, Vladimir; Rose, Ruth-Sarah; Trousil, Sebastian; Mermoud, Jacqueline E; Dingwall, Colin.

Affiliation

Hughes M; Pharmaceutical Sciences Division, King's College London, London, UK.

J Neurochem ; 114(3): 832-42, 2010 Aug.

Article in En | MEDLINE | ID: mdl-20477946

Subject(s)

Amyloid beta-Protein Precursor/physiology; Mevalonic Acid/antagonists & inhibitors; Neurites/metabolism; Alzheimer Disease/drug therapy; Alzheimer Disease/metabolism; Alzheimer Disease/pathology; Cell Adhesion/drug effects; Cell Adhesion/physiology; Cell Line, Tumor; Cell Shape/physiology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Mevalonic Acid/metabolism; Microscopy, Video/methods; Neurites/drug effects; Neurites/pathology; Neuroblastoma/metabolism; Neuroblastoma/pathology; Neurogenesis/drug effects; Neurogenesis/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurites / Amyloid beta-Protein Precursor / Mevalonic Acid Limits: Humans Language: En Journal: J Neurochem Year: 2010 Type: Article Affiliation country: United kingdom

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