Efficacy and safety of different doses and retreatment of rituximab: a randomised, placebo-controlled trial in patients who are biological naive with active rheumatoid arthritis and an inadequate response to methotrexate (Study Evaluating Rituximab's Efficacy in MTX iNadequate rEsponders (SERENE)).

Emery, P; Deodhar, A; Rigby, W F; Isaacs, J D; Combe, B; Racewicz, A J; Latinis, K; Abud-Mendoza, C; Szczepanski, L J; Roschmann, R A; Chen, A; Armstrong, G K; Douglass, W; Tyrrell, H

Emery, P; Deodhar, A; Rigby, W F; Isaacs, J D; Combe, B; Racewicz, A J; Latinis, K; Abud-Mendoza, C; Szczepanski, L J; Roschmann, R A; Chen, A; Armstrong, G K; Douglass, W; Tyrrell, H.

Affiliation

Emery P; Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds. p.emery@leeds.ac.uk [corrected]

Ann Rheum Dis ; 69(9): 1629-35, 2010 Sep.

Article in En | MEDLINE | ID: mdl-20488885

Subject(s)

Antibodies, Monoclonal/administration & dosage; Antirheumatic Agents/administration & dosage; Arthritis, Rheumatoid/drug therapy; Adult; Aged; Antibodies, Monoclonal/adverse effects; Antibodies, Monoclonal/therapeutic use; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents/adverse effects; Antirheumatic Agents/therapeutic use; Arthritis, Rheumatoid/immunology; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Methotrexate/adverse effects; Methotrexate/therapeutic use; Middle Aged; Rituximab; Severity of Illness Index; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Antirheumatic Agents / Antibodies, Monoclonal Type of study: Clinical_trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Ann Rheum Dis Year: 2010 Type: Article

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