Sorafenib downregulates ERK/Akt and STAT3 survival pathways and induces apoptosis in a human neuroblastoma cell line.

Chai, Hong; Luo, Annie Z; Weerasinghe, Priya; Brown, Robert E

Chai, Hong; Luo, Annie Z; Weerasinghe, Priya; Brown, Robert E.

Affiliation

Chai H; Department of Pathology and Laboratory Medicine, University of Texas Health Science Center-Medical School at Houston, MSB 2.286, Houston, TX 77030, USA.

Int J Clin Exp Pathol ; 3(4): 408-15, 2010 Apr 23.

Article in En | MEDLINE | ID: mdl-20490331

Subject(s)

Apoptosis/drug effects; Benzenesulfonates/pharmacology; Neuroblastoma/metabolism; Pyridines/pharmacology; Signal Transduction/drug effects; Antineoplastic Agents/pharmacology; Blotting, Western; Cell Line, Tumor; Cell Survival/drug effects; Down-Regulation/drug effects; Extracellular Signal-Regulated MAP Kinases/drug effects; Extracellular Signal-Regulated MAP Kinases/metabolism; Humans; In Situ Nick-End Labeling; Niacinamide/analogs & derivatives; Oncogene Protein v-akt/drug effects; Oncogene Protein v-akt/metabolism; Phenylurea Compounds; Phosphorylation/drug effects; STAT3 Transcription Factor/drug effects; STAT3 Transcription Factor/metabolism; Sorafenib

Key words

Akt1/2/3 Protein Kinase; Apoptosis; Neuroblastoma; Signal Transducer and Activator of Transcription 3; Sorafenib

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Benzenesulfonates / Signal Transduction / Apoptosis / Neuroblastoma Limits: Humans Language: En Journal: Int J Clin Exp Pathol Journal subject: PATOLOGIA Year: 2010 Type: Article Affiliation country: United States

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