The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity.

Campbell, Clinton J V; Lee, Jung Bok; Levadoux-Martin, Marilyne; Wynder, Tracy; Xenocostas, Anargyros; Leber, Brian; Bhatia, Mickie

Campbell, Clinton J V; Lee, Jung Bok; Levadoux-Martin, Marilyne; Wynder, Tracy; Xenocostas, Anargyros; Leber, Brian; Bhatia, Mickie.

Affiliation

Campbell CJ; Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada.

Blood ; 116(9): 1433-42, 2010 Sep 02.

Article in En | MEDLINE | ID: mdl-20525924

Subject(s)

Cell Proliferation; Hematopoiesis/physiology; Hematopoietic Stem Cells/cytology; Hematopoietic Stem Cells/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Animals; Blotting, Western; Bone Marrow Cells/drug effects; Bone Marrow Cells/metabolism; Cell Differentiation/drug effects; Cells, Cultured; Female; Fetal Blood/drug effects; Fetal Blood/metabolism; Flow Cytometry; Humans; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2/genetics; Pyrroles/pharmacology; RNA, Messenger/genetics; Reverse Transcriptase Polymerase Chain Reaction; beta 2-Microglobulin/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / Proto-Oncogene Proteins c-bcl-2 / Cell Proliferation / Hematopoiesis Limits: Animals / Female / Humans / Male Language: En Journal: Blood Year: 2010 Type: Article Affiliation country: Canada

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