Secreted frizzled related protein 4 reduces fibrosis scar size and ameliorates cardiac function after ischemic injury.

Matsushima, Kentaro; Suyama, Takashi; Takenaka, Chiemi; Nishishita, Naoki; Ikeda, Keiko; Ikada, Yoshito; Sawa, Yoshiki; Jakt, Lars Martin; Mori, Hajime; Kawamata, Shin

Matsushima, Kentaro; Suyama, Takashi; Takenaka, Chiemi; Nishishita, Naoki; Ikeda, Keiko; Ikada, Yoshito; Sawa, Yoshiki; Jakt, Lars Martin; Mori, Hajime; Kawamata, Shin.

Affiliation

Matsushima K; Foundation for Biomedical Research and Innovation TR1308, Kobe, Japan.

Tissue Eng Part A ; 16(11): 3329-41, 2010 Nov.

Article in En | MEDLINE | ID: mdl-20528676

Subject(s)

Heart Function Tests; Myocardial Ischemia/drug therapy; Myocardial Ischemia/physiopathology; Proto-Oncogene Proteins/therapeutic use; Animals; Biocompatible Materials/pharmacology; Cardiotonic Agents/pharmacology; Cardiotonic Agents/therapeutic use; Disease Models, Animal; Drug Delivery Systems; Fibrosis; Humans; Injections, Intramuscular; Male; Myocardial Ischemia/genetics; Myocardial Ischemia/pathology; Proto-Oncogene Proteins/administration & dosage; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins/pharmacology; Rats; Rats, Sprague-Dawley; Recombinant Proteins/administration & dosage; Recombinant Proteins/pharmacology; Recombinant Proteins/therapeutic use; Signal Transduction/drug effects; Transcription, Genetic/drug effects; Up-Regulation/genetics; Wnt Proteins/metabolism; beta Catenin/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins / Myocardial Ischemia / Heart Function Tests Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Tissue Eng Part A Journal subject: BIOTECNOLOGIA / HISTOLOGIA Year: 2010 Type: Article Affiliation country: Japan

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