Efficient RNA-targeting by the introduction of aromatic stacking in the duplex major groove via 5-(1-phenyl-1,2,3-triazol-4-yl)-2'-deoxyuridines.

Andersen, Nicolai Krog; Chandak, Navneet; Brulíková, Lucie; Kumar, Pawan; Jensen, Michael Dalager; Jensen, Frank; Sharma, Pawan K; Nielsen, Poul

Andersen, Nicolai Krog; Chandak, Navneet; Brulíková, Lucie; Kumar, Pawan; Jensen, Michael Dalager; Jensen, Frank; Sharma, Pawan K; Nielsen, Poul.

Affiliation

Andersen NK; Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, 5230 Odense M, Denmark.

Bioorg Med Chem ; 18(13): 4702-10, 2010 Jul 01.

Article in En | MEDLINE | ID: mdl-20570158

Subject(s)

Deoxyuridine/chemistry; RNA/chemistry; Alkynes/chemistry; Azides/chemistry; Catalysis; Circular Dichroism; Copper/chemistry; DNA/chemistry; Deoxyuridine/chemical synthesis; Deoxyuridine/pharmacology; Models, Molecular; Nucleic Acid Hybridization

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA / Deoxyuridine Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Type: Article Affiliation country: Denmark

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