Peanut-induced intestinal allergy is mediated through a mast cell-IgE-FcepsilonRI-IL-13 pathway.

Wang, Meiqin; Takeda, Katsuyuki; Shiraishi, Yoshiki; Okamoto, Masakazu; Dakhama, Azzeddine; Joetham, Anthony; Gelfand, Erwin W

Wang, Meiqin; Takeda, Katsuyuki; Shiraishi, Yoshiki; Okamoto, Masakazu; Dakhama, Azzeddine; Joetham, Anthony; Gelfand, Erwin W.

Affiliation

Wang M; Division of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colo, USA.

J Allergy Clin Immunol ; 126(2): 306-16, 316.e1-12, 2010 Aug.

Article in En | MEDLINE | ID: mdl-20624645

Subject(s)

Arachis/adverse effects; Immunoglobulin E/immunology; Interleukin-13/immunology; Mast Cells/immunology; Peanut Hypersensitivity/immunology; Receptors, IgE/immunology; Animals; Cell Differentiation/drug effects; Cell Differentiation/immunology; Immunity, Mucosal/genetics; Immunity, Mucosal/immunology; Immunoglobulin E/genetics; Immunoglobulin Fc Fragments/genetics; Immunoglobulin Fc Fragments/pharmacology; Inflammation/genetics; Inflammation/immunology; Inflammation/pathology; Interleukin-13/antagonists & inhibitors; Interleukin-13/genetics; Interleukin-13 Receptor alpha2 Subunit/genetics; Interleukin-17/genetics; Interleukin-17/immunology; Interleukin-4/genetics; Interleukin-4/immunology; Interleukin-6/genetics; Interleukin-6/immunology; Intestines/immunology; Intestines/pathology; Mast Cells/pathology; Mice; Mice, Inbred BALB C; Mice, Knockout; Peanut Hypersensitivity/drug therapy; Peanut Hypersensitivity/genetics; Peanut Hypersensitivity/pathology; Receptors, IgE/genetics; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/pharmacology

Key words

FcÎµRI; IL-13; IgE; Peanut; intestinal allergy; mast cell

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arachis / Immunoglobulin E / Receptors, IgE / Interleukin-13 / Peanut Hypersensitivity / Mast Cells Type of study: Prognostic_studies Language: En Journal: J Allergy Clin Immunol Year: 2010 Type: Article Affiliation country: United States

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