Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment.

Nistala, Kiran; Adams, Stuart; Cambrook, Helen; Ursu, Simona; Olivito, Biagio; de Jager, Wilco; Evans, Jamie G; Cimaz, Rolando; Bajaj-Elliott, Mona; Wedderburn, Lucy R

Nistala, Kiran; Adams, Stuart; Cambrook, Helen; Ursu, Simona; Olivito, Biagio; de Jager, Wilco; Evans, Jamie G; Cimaz, Rolando; Bajaj-Elliott, Mona; Wedderburn, Lucy R.

Affiliation

Nistala K; Rheumatology Unit, University College London Institute of Child Health, London WC1N 1EH, United Kingdom. K.Nistala@ich.ucl.ac.uk

Proc Natl Acad Sci U S A ; 107(33): 14751-6, 2010 Aug 17.

Article in En | MEDLINE | ID: mdl-20679229

Subject(s)

Arthritis, Juvenile/immunology; Interleukin-17/immunology; T-Lymphocytes, Helper-Inducer/immunology; Th1 Cells/immunology; Amino Acid Sequence; Arthritis, Juvenile/genetics; Arthritis, Juvenile/metabolism; Base Sequence; Cell Lineage/genetics; Cell Lineage/immunology; Child; Flow Cytometry; Gene Expression; Humans; Interferon-gamma/genetics; Interferon-gamma/immunology; Interferon-gamma/metabolism; Interleukin-12/immunology; Interleukin-12/metabolism; Interleukin-17/genetics; Interleukin-17/metabolism; Molecular Sequence Data; NK Cell Lectin-Like Receptor Subfamily B/genetics; NK Cell Lectin-Like Receptor Subfamily B/immunology; NK Cell Lectin-Like Receptor Subfamily B/metabolism; Nuclear Receptor Subfamily 1, Group F, Member 3/genetics; Nuclear Receptor Subfamily 1, Group F, Member 3/immunology; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism; Receptors, CCR6/genetics; Receptors, CCR6/immunology; Receptors, CCR6/metabolism; Reverse Transcriptase Polymerase Chain Reaction; T-Box Domain Proteins/genetics; T-Box Domain Proteins/immunology; T-Box Domain Proteins/metabolism; T-Lymphocytes, Helper-Inducer/metabolism; Th1 Cells/metabolism; Transforming Growth Factor beta/immunology; Transforming Growth Factor beta/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Juvenile / T-Lymphocytes, Helper-Inducer / Th1 Cells / Interleukin-17 Type of study: Prognostic_studies Language: En Journal: Proc Natl Acad Sci U S A Year: 2010 Type: Article Affiliation country: United kingdom

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