Transition state of ADP-ribosylation of acetyllysine catalyzed by Archaeoglobus fulgidus Sir2 determined by kinetic isotope effects and computational approaches.

Cen, Yana; Sauve, Anthony A

Cen, Yana; Sauve, Anthony A.

Affiliation

Cen Y; Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10065, USA.

J Am Chem Soc ; 132(35): 12286-98, 2010 Sep 08.

Article in En | MEDLINE | ID: mdl-20718419

Subject(s)

Adenosine Diphosphate Ribose/metabolism; Archaeoglobus fulgidus/enzymology; Computer Simulation; Lysine/analogs & derivatives; Sirtuin 2/metabolism; Acetylation; Adenosine Diphosphate Ribose/chemistry; Biocatalysis; Kinetics; Lysine/chemistry; Lysine/metabolism; NAD/chemistry; Sirtuin 2/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Computer Simulation / Adenosine Diphosphate Ribose / Archaeoglobus fulgidus / Sirtuin 2 / Lysine Language: En Journal: J Am Chem Soc Year: 2010 Type: Article Affiliation country: United States

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