Comparison of ventricular and intravenous lentiviral-mediated gene therapy for murine MPS VII.

Bielicki, Julie; McIntyre, Chantelle; Anson, Donald S

Bielicki, Julie; McIntyre, Chantelle; Anson, Donald S.

Affiliation

Bielicki J; Genetics and Molecular Pathology, SA Pathology, North Adelaide, SA, 5006, Australia.

Mol Genet Metab ; 101(4): 370-82, 2010 Dec.

Article in En | MEDLINE | ID: mdl-20864369

Subject(s)

Genetic Therapy/methods; Genetic Vectors/administration & dosage; Glucuronidase/deficiency; Glucuronidase/genetics; Lentivirus/genetics; Mucopolysaccharidosis VII/genetics; Mucopolysaccharidosis VII/therapy; Animals; Antibodies/immunology; Brain/cytology; Brain/pathology; Cell Line; Eye/metabolism; Eye/pathology; Gene Transfer Techniques; Genetic Vectors/genetics; Glucuronidase/immunology; Glucuronidase/metabolism; Glycosaminoglycans/urine; Humans; Infusion Pumps; Infusions, Intraventricular; Injections, Intravenous; Lateral Ventricles; Lysosomes/metabolism; Mice; Mucopolysaccharidosis VII/pathology; Uronic Acids/metabolism; beta-N-Acetylhexosaminidases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Therapy / Mucopolysaccharidosis VII / Lentivirus / Genetic Vectors / Glucuronidase Limits: Animals / Humans Language: En Journal: Mol Genet Metab Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / METABOLISMO Year: 2010 Type: Article Affiliation country: Australia

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