Azathioprine-induced carcinogenesis in mice according to Msh2 genotype.

Chalastanis, Alexandra; Penard-Lacronique, Virginie; Svrcek, Magali; Defaweux, Valérie; Antoine, Nadine; Buhard, Olivier; Dumont, Sylvie; Fabiani, Bettina; Renault, Isabelle; Tubacher, Emmanuel; Fléjou, Jean-François; Te Riele, Hein; Duval, Alex; Muleris, Martine

Chalastanis, Alexandra; Penard-Lacronique, Virginie; Svrcek, Magali; Defaweux, Valérie; Antoine, Nadine; Buhard, Olivier; Dumont, Sylvie; Fabiani, Bettina; Renault, Isabelle; Tubacher, Emmanuel; Fléjou, Jean-François; Te Riele, Hein; Duval, Alex; Muleris, Martine.

Affiliation

Chalastanis A; INSERM, UMRS, Paris, France.

J Natl Cancer Inst ; 102(22): 1731-40, 2010 Nov 17.

Article in En | MEDLINE | ID: mdl-20923998

Subject(s)

Antimetabolites, Antineoplastic/toxicity; Azathioprine/toxicity; Carcinogens/toxicity; DNA Mismatch Repair/genetics; Immunosuppressive Agents/toxicity; Lymphoma/chemically induced; Lymphoma/genetics; MutS Homolog 2 Protein/genetics; Administration, Oral; Animals; DNA, Neoplasm/genetics; Disease Models, Animal; Genotype; Immunohistochemistry; Kaplan-Meier Estimate; Loss of Heterozygosity; Lymphoma/pathology; Mice; Microsatellite Instability/drug effects; Polymerase Chain Reaction; Research Design

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azathioprine / Carcinogens / MutS Homolog 2 Protein / DNA Mismatch Repair / Immunosuppressive Agents / Lymphoma / Antimetabolites, Antineoplastic Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: J Natl Cancer Inst Year: 2010 Type: Article Affiliation country: France

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