Yeast-elicited cross-reactive antibodies to HIV Env glycans efficiently neutralize virions expressing exclusively high-mannose N-linked glycans.

Agrawal-Gamse, Caroline; Luallen, Robert J; Liu, Bingfen; Fu, Hu; Lee, Fang-Hua; Geng, Yu; Doms, Robert W

Agrawal-Gamse, Caroline; Luallen, Robert J; Liu, Bingfen; Fu, Hu; Lee, Fang-Hua; Geng, Yu; Doms, Robert W.

Affiliation

Agrawal-Gamse C; Department of Microbiology, University of Pennsylvania, 3610 Hamilton Walk, 225A Johnson Pavilion, Philadelphia, PA 19104, USA.

J Virol ; 85(1): 470-80, 2011 Jan.

Article in En | MEDLINE | ID: mdl-20962094

Subject(s)

Antibodies, Neutralizing/immunology; HIV Antibodies/immunology; HIV Envelope Protein gp120/immunology; Polysaccharides/immunology; Saccharomyces cerevisiae/immunology; Virion/immunology; Animals; Antibodies, Monoclonal/immunology; Antibodies, Monoclonal/metabolism; Broadly Neutralizing Antibodies; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Glycoproteins/metabolism; HIV Antibodies/metabolism; HIV Envelope Protein gp120/metabolism; Humans; Immunization; Mannose/metabolism; Microarray Analysis; Neutralization Tests; Polysaccharides/metabolism; Rabbits; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Virion/metabolism

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polysaccharides / Saccharomyces cerevisiae / Virion / HIV Antibodies / HIV Envelope Protein gp120 / Antibodies, Neutralizing Type of study: Clinical_trials Limits: Animals / Humans Language: En Journal: J Virol Year: 2011 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google