Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts.

Kojima, Yasushi; Acar, Ahmet; Eaton, Elinor Ng; Mellody, Kieran T; Scheel, Christina; Ben-Porath, Ittai; Onder, Tamer T; Wang, Zhigang C; Richardson, Andrea L; Weinberg, Robert A; Orimo, Akira

Kojima, Yasushi; Acar, Ahmet; Eaton, Elinor Ng; Mellody, Kieran T; Scheel, Christina; Ben-Porath, Ittai; Onder, Tamer T; Wang, Zhigang C; Richardson, Andrea L; Weinberg, Robert A; Orimo, Akira.

Affiliation

Kojima Y; Cancer Research-UK Stromal-Tumor Interaction Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester M20 4BX, United Kingdom.

Proc Natl Acad Sci U S A ; 107(46): 20009-14, 2010 Nov 16.

Article in En | MEDLINE | ID: mdl-21041659

Subject(s)

Autocrine Communication; Breast Neoplasms/pathology; Chemokine CXCL12/metabolism; Mammary Glands, Human/pathology; Myofibroblasts/pathology; Signal Transduction; Transforming Growth Factor beta/metabolism; Animals; Breast Neoplasms/metabolism; Cell Differentiation; Female; Humans; Mammary Glands, Human/metabolism; Mice; Neoplasm Invasiveness; Receptors, CXCR4/metabolism; Stromal Cells/metabolism; Stromal Cells/pathology; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Signal Transduction / Transforming Growth Factor beta / Autocrine Communication / Mammary Glands, Human / Chemokine CXCL12 / Myofibroblasts Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2010 Type: Article Affiliation country: United kingdom

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