Induction of hippocampal neurogenesis by a tolerogenic peptide that ameliorates lupus manifestations.
J Neuroimmunol
; 232(1-2): 151-7, 2011 Mar.
Article
in En
| MEDLINE
| ID: mdl-21129786
ABSTRACT
To determine the effect of the tolerogenic peptide hCDR1 on hippocampal neurogenesis, we treated SLE-afflicted (NZBxNZW)F1 mice with hCDR1 (once a week for 10weeks). The treatment resulted in the up-regulation of neurogenesis in the dentate gyrus and restored the NeuN immunoreactivity in brain hippocampi of the mice in association with increased gene expression of IGF-1, NGF and BDNF. Furthermore, hCDR1 treatment significantly up-regulated p-ERK and p-Akt that are suggested to be key components in mediating growth factor-induced neurogenesis. The observed effects of hCDR1 on hippocampal-neurogenesis and on associated signaling pathways suggest a potential role for hCDR1 in CNS lupus.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Fragments
/
Lupus Vasculitis, Central Nervous System
/
Neurogenesis
/
Hippocampus
/
Antibodies, Monoclonal
Type of study:
Prognostic_studies
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
J Neuroimmunol
Year:
2011
Type:
Article
Affiliation country:
Israel