Tumour necrosis factor alpha-driven IL-32 expression in rheumatoid arthritis synovial tissue amplifies an inflammatory cascade.

Heinhuis, Bas; Koenders, Marije I; van Riel, Piet L; van de Loo, Fons A; Dinarello, Charles A; Netea, Mihai G; van den Berg, Wim B; Joosten, Leo A B

Heinhuis, Bas; Koenders, Marije I; van Riel, Piet L; van de Loo, Fons A; Dinarello, Charles A; Netea, Mihai G; van den Berg, Wim B; Joosten, Leo A B.

Affiliation

Heinhuis B; Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB, Nijmegen, The Netherlands. s.heinhuis@reuma.umcn.nl

Ann Rheum Dis ; 70(4): 660-7, 2011 Apr.

Article in En | MEDLINE | ID: mdl-21187297

Subject(s)

Arthritis, Rheumatoid/metabolism; Interleukins/biosynthesis; Synovial Membrane/metabolism; Tumor Necrosis Factor-alpha/physiology; Antirheumatic Agents/pharmacology; Arthritis, Rheumatoid/drug therapy; Arthritis, Rheumatoid/pathology; Cells, Cultured; Fibroblasts/metabolism; Gene Silencing; Humans; Inflammation Mediators/metabolism; Interleukin-1beta/biosynthesis; Interleukin-1beta/genetics; Interleukin-6/biosynthesis; Interleukin-8/biosynthesis; Interleukin-8/genetics; Lipopolysaccharides/pharmacology; RNA, Messenger/genetics; Synovial Membrane/drug effects; Synovial Membrane/pathology; Tumor Necrosis Factor-alpha/antagonists & inhibitors; Tumor Necrosis Factor-alpha/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Synovial Membrane / Interleukins / Tumor Necrosis Factor-alpha Limits: Humans Language: En Journal: Ann Rheum Dis Year: 2011 Type: Article Affiliation country: Netherlands

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