Soluble E-cadherin promotes cell survival by activating epidermal growth factor receptor.
Exp Cell Res
; 317(6): 838-48, 2011 Apr 01.
Article
in En
| MEDLINE
| ID: mdl-21211535
ABSTRACT
High levels of the soluble form of E-cadherin can be found in the serum of cancer patients and are associated with poor prognosis. Despite the possible predictive value of soluble E-cadherin, little is understood concerning its patho-physiological consequences in tumor progression. In this study, we show that soluble E-cadherin facilitates cell survival via functional interaction with cellular E-cadherin. Exposure of cells to a recombinant form of soluble E-cadherin, at a concentration found in cancer patient's serum, prevents apoptosis due to serum/growth factor withdrawal, and inhibits epithelial lumen formation, a process that requires apoptosis. Further, soluble E-cadherin-mediated cell survival involves activation of the epidermal growth factor receptor (EGFR) and EGFR-mediated activation of both phosphoinositide-3 kinase (PI3K)/AKT and ERK1/2 signaling pathways. These results are evidence of a complex functional interplay between EGFR and E-cadherin and also suggest that the presence of soluble E-cadherin in cancer patients' sera might have relevance to cell survival and tumor progression.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cadherins
/
Gene Expression Regulation
/
Apoptosis
/
ErbB Receptors
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Exp Cell Res
Year:
2011
Type:
Article
Affiliation country:
United States