Synthesis of bi-substrate state mimics of dihydropteroate synthase as potential inhibitors and molecular probes.

Qi, Jianjun; Virga, Kristopher G; Das, Sourav; Zhao, Ying; Yun, Mi-Kyung; White, Stephen W; Lee, Richard E

Qi, Jianjun; Virga, Kristopher G; Das, Sourav; Zhao, Ying; Yun, Mi-Kyung; White, Stephen W; Lee, Richard E.

Affiliation

Qi J; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 847 Monroe Ave., Rm327, Memphis, TN 38613, USA.

Bioorg Med Chem ; 19(3): 1298-305, 2011 Feb 01.

Article in En | MEDLINE | ID: mdl-21216602

Subject(s)

Anti-Bacterial Agents/chemical synthesis; Anti-Bacterial Agents/pharmacology; Dihydropteroate Synthase/antagonists & inhibitors; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Molecular Probes; Organophosphonates/chemical synthesis; Pyrimidinones/chemical synthesis; Anti-Bacterial Agents/chemistry; Bacillus anthracis/drug effects; Bacillus anthracis/enzymology; Dihydropteroate Synthase/metabolism; Drug Design; Models, Molecular; Molecular Structure; Organophosphonates/chemistry; Organophosphonates/pharmacology; Pterins/chemistry; Pyrimidinones/chemistry; Pyrimidinones/pharmacology; Structure-Activity Relationship; Sulfonamides/chemistry; Sulfonamides/pharmacology

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidinones / Molecular Probes / Dihydropteroate Synthase / Enzyme Inhibitors / Organophosphonates / Anti-Bacterial Agents Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google