[Pharmacological correction of the cytogenetic effects of cisplatin].
Eksp Klin Farmakol
; 73(10): 37-9, 2010 Oct.
Article
in Ru
| MEDLINE
| ID: mdl-21254513
ABSTRACT
Beginning with the first hours of experiments, cisplatin evoked an increase of chromosomal aberrations in CBA/CaLac bone marrow cells. Significant increase of structural infringements of chromosomes due to chromatid breaks was revealed in metaphase plates of murine bone marrow preparations through 24 h after cisplatin intraperitoneal introduction. In late terms of research (90th day), the high level of aberrations of chromosomes was retained. The most pronounced correction of cisplatin mutagenicity was achieved using a preliminary course of thiophan introduction.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thiophenes
/
Chromosome Aberrations
/
Cisplatin
Limits:
Animals
Language:
Ru
Journal:
Eksp Klin Farmakol
Journal subject:
FARMACOLOGIA
Year:
2010
Type:
Article