mGluR5 negative allosteric modulators overview: a medicinal chemistry approach towards a series of novel therapeutic agents.

Rocher, Jean-Philippe; Bonnet, Béatrice; Boléa, Christelle; Lütjens, Robert; Le Poul, Emmanuel; Poli, Sonia; Epping-Jordan, Mark; Bessis, Anne-Sophie; Ludwig, Bernard; Mutel, Vincent

Rocher, Jean-Philippe; Bonnet, Béatrice; Boléa, Christelle; Lütjens, Robert; Le Poul, Emmanuel; Poli, Sonia; Epping-Jordan, Mark; Bessis, Anne-Sophie; Ludwig, Bernard; Mutel, Vincent.

Affiliation

Rocher JP; Addex Pharma SA, Core Chemistry Department, Chemin des Aulx 12, 1228 Plan-les-Ouates Geneva, Switzerland. jean-philippe.rocher@addexpharma.com

Curr Top Med Chem ; 11(6): 680-95, 2011.

Article in En | MEDLINE | ID: mdl-21261592

Subject(s)

Heterocyclic Compounds/pharmacology; Pyridines/pharmacology; Receptors, Metabotropic Glutamate/antagonists & inhibitors; Allosteric Regulation/drug effects; Chemistry, Pharmaceutical; Drug Design; Heterocyclic Compounds/chemical synthesis; Heterocyclic Compounds/chemistry; Positron-Emission Tomography; Pyridines/chemical synthesis; Pyridines/chemistry; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate/chemistry; Receptors, Metabotropic Glutamate/metabolism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Receptors, Metabotropic Glutamate / Heterocyclic Compounds Language: En Journal: Curr Top Med Chem Journal subject: QUIMICA Year: 2011 Type: Article Affiliation country: Switzerland

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