Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area.

Khor, Chiea Chuen; Ramdas, Wishal D; Vithana, Eranga N; Cornes, Belinda K; Sim, Xueling; Tay, Wan-Ting; Saw, Seang-Mei; Zheng, Yingfeng; Lavanya, Raghavan; Wu, Renyi; Wang, Jie Jin; Mitchell, Paul; Uitterlinden, André G; Rivadeneira, Fernando; Teo, Yik-Ying; Chia, Kee-Seng; Seielstad, Mark; Hibberd, Martin; Vingerling, Johannes R; Klaver, Caroline C W; Jansonius, Nomdo M; Tai, E-Shyong; Wong, Tien-Yin; van Duijn, Cornelia M; Aung, Tin

Khor, Chiea Chuen; Ramdas, Wishal D; Vithana, Eranga N; Cornes, Belinda K; Sim, Xueling; Tay, Wan-Ting; Saw, Seang-Mei; Zheng, Yingfeng; Lavanya, Raghavan; Wu, Renyi; Wang, Jie Jin; Mitchell, Paul; Uitterlinden, André G; Rivadeneira, Fernando; Teo, Yik-Ying; Chia, Kee-Seng; Seielstad, Mark; Hibberd, Martin; Vingerling, Johannes R; Klaver, Caroline C W; Jansonius, Nomdo M; Tai, E-Shyong; Wong, Tien-Yin; van Duijn, Cornelia M; Aung, Tin.

Affiliation

Khor CC; Infectious Diseases, Genome Institute of Singapore, A*STAR, Singapore.

Hum Mol Genet ; 20(9): 1864-72, 2011 May 01.

Article in En | MEDLINE | ID: mdl-21307088

Subject(s)

Asian People/genetics; Basic Helix-Loop-Helix Transcription Factors/genetics; CARD Signaling Adaptor Proteins/genetics; Genetic Predisposition to Disease; Genome-Wide Association Study; Glaucoma/genetics; Optic Disk/chemistry; Proteoglycans/genetics; Receptors, Transforming Growth Factor beta/genetics; Adult; Aged; Aged, 80 and over; Basic Helix-Loop-Helix Transcription Factors/metabolism; CARD Signaling Adaptor Proteins/metabolism; Chromosomes, Human, Pair 22/genetics; Cohort Studies; Female; Glaucoma/ethnology; Humans; Male; Middle Aged; Optic Disk/metabolism; Polymorphism, Single Nucleotide; Proteoglycans/metabolism; Receptors, Transforming Growth Factor beta/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Optic Disk / Proteoglycans / Glaucoma / Receptors, Transforming Growth Factor beta / Genetic Predisposition to Disease / Asian People / Basic Helix-Loop-Helix Transcription Factors / CARD Signaling Adaptor Proteins / Genome-Wide Association Study Type of study: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2011 Type: Article Affiliation country: Singapore

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