Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation.

Dartt, Darlene A; Hodges, Robin R; Li, Dayu; Shatos, Marie A; Lashkari, Kameran; Serhan, Charles N

Dartt, Darlene A; Hodges, Robin R; Li, Dayu; Shatos, Marie A; Lashkari, Kameran; Serhan, Charles N.

Affiliation

Dartt DA; Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA. darlene.dartt@schepens.harvard.edu

J Immunol ; 186(7): 4455-66, 2011 Apr 01.

Article in En | MEDLINE | ID: mdl-21357260

Subject(s)

Conjunctiva/metabolism; Conjunctiva/pathology; Docosahexaenoic Acids/therapeutic use; Eicosapentaenoic Acid/analogs & derivatives; Goblet Cells/metabolism; Goblet Cells/pathology; Leukotriene D4/physiology; Leukotriene E4/physiology; Aged; Animals; Cells, Cultured; Docosahexaenoic Acids/biosynthesis; Docosahexaenoic Acids/physiology; Eicosapentaenoic Acid/biosynthesis; Eicosapentaenoic Acid/physiology; Eicosapentaenoic Acid/therapeutic use; Female; Humans; Inflammation Mediators/antagonists & inhibitors; Inflammation Mediators/physiology; Inflammation Mediators/therapeutic use; Leukotriene C4/antagonists & inhibitors; Leukotriene C4/physiology; Leukotriene D4/antagonists & inhibitors; Leukotriene E4/antagonists & inhibitors; Male; Middle Aged; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, Leukotriene/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Eicosapentaenoic Acid / Docosahexaenoic Acids / Leukotriene E4 / Leukotriene D4 / Conjunctiva / Goblet Cells Limits: Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: J Immunol Year: 2011 Type: Article Affiliation country: United States

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