Novel cytochrome p450 bioactivation of a terminal phenyl acetylene group: formation of a one-carbon loss benzaldehyde and other oxidative products in the presence of N-acetyl cysteine or glutathione.

Subramanian, Raju; Tam, Janet; Aidasani, Divesh; Reid, Darren L; Skiles, Gary L

Subramanian, Raju; Tam, Janet; Aidasani, Divesh; Reid, Darren L; Skiles, Gary L.

Affiliation

Subramanian R; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California 91320, United States. rajus@amgen.com

Chem Res Toxicol ; 24(5): 677-86, 2011 May 16.

Article in En | MEDLINE | ID: mdl-21395287

Subject(s)

Acetylcysteine/metabolism; Acetylene/metabolism; Benzaldehydes/metabolism; Cytochrome P-450 Enzyme System/metabolism; Glutathione/metabolism; Animals; Antioxidants/pharmacology; Ascorbic Acid/pharmacology; Cattle; Chelating Agents/pharmacology; Deferoxamine/pharmacology; Dogs; Humans; Male; Oxidation-Reduction; Rats; Rats, Sprague-Dawley

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcysteine / Acetylene / Benzaldehydes / Cytochrome P-450 Enzyme System / Glutathione Limits: Animals / Humans / Male Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2011 Type: Article Affiliation country: United States

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