CGX-1007 prevents excitotoxic cell death via actions at multiple types of NMDA receptors.

Alex, Anitha B; Saunders, Gerald W; Dalpé-Charron, Alexandre; Reilly, Christopher A; Wilcox, Karen S

Alex, Anitha B; Saunders, Gerald W; Dalpé-Charron, Alexandre; Reilly, Christopher A; Wilcox, Karen S.

Affiliation

Alex AB; Department of Pharmacology & Toxicology,Anticonvulsant Drug Development Program, University of Utah, 417 Wakara Way, Salt Lake City, UT 84108, USA.

Neurotoxicology ; 32(4): 392-9, 2011 Aug.

Article in En | MEDLINE | ID: mdl-21396956

Subject(s)

Conotoxins/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Hippocampus/drug effects; Neuroprotective Agents/pharmacology; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors; Animals; Animals, Newborn; Cell Death/drug effects; Cytoprotection; Dose-Response Relationship, Drug; HEK293 Cells; Hippocampus/metabolism; Hippocampus/pathology; Humans; Membrane Potentials; Mice; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate/genetics; Receptors, N-Methyl-D-Aspartate/metabolism; Time Factors; Tissue Culture Techniques; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, N-Methyl-D-Aspartate / Neuroprotective Agents / Excitatory Amino Acid Antagonists / Conotoxins / Hippocampus Limits: Animals / Humans Language: En Journal: Neurotoxicology Year: 2011 Type: Article Affiliation country: United States

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