Methylsulfonylpyrazolyl oxadiazoles and thiadiazoles as potent, orally bioavailable cannabinoid-1 receptor antagonists for the treatment of obesity.

Seo, Hee Jeong; Kim, Min Ju; Song, Kwang-Seop; Lee, Sung-Han; Jung, Myung Eun; Kim, Mi-Soon; Park, Hyun-Ju; Yoo, Jakyung; Chang, Chong-Hwan; Kim, Jeongmin; Lee, Jinhwa

Seo, Hee Jeong; Kim, Min Ju; Song, Kwang-Seop; Lee, Sung-Han; Jung, Myung Eun; Kim, Mi-Soon; Park, Hyun-Ju; Yoo, Jakyung; Chang, Chong-Hwan; Kim, Jeongmin; Lee, Jinhwa.

Affiliation

Seo HJ; Central Research Laboratories, Green Cross Corporation, 303 Bojeong-dong, Giheung-gu, Yongin 446-770, Korea.

Future Med Chem ; 1(5): 947-67, 2009 Aug.

Article in En | MEDLINE | ID: mdl-21426091

Subject(s)

Anti-Obesity Agents/chemistry; Obesity/drug therapy; Oxadiazoles/chemistry; Pyrazoles/chemistry; Receptor, Cannabinoid, CB1/antagonists & inhibitors; Thiadiazoles/chemistry; Administration, Oral; Animals; Anti-Obesity Agents/pharmacokinetics; Anti-Obesity Agents/therapeutic use; Binding Sites; Biological Availability; Computer Simulation; Humans; Mice; Oxadiazoles/pharmacokinetics; Oxadiazoles/therapeutic use; Pyrazoles/pharmacokinetics; Pyrazoles/therapeutic use; Rats; Receptor, Cannabinoid, CB1/metabolism; Structure-Activity Relationship; Thiadiazoles/pharmacokinetics; Thiadiazoles/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxadiazoles / Pyrazoles / Thiadiazoles / Anti-Obesity Agents / Receptor, Cannabinoid, CB1 / Obesity Limits: Animals / Humans Language: En Journal: Future Med Chem Year: 2009 Type: Article

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