Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis.

Bhui, Kulpreet; Tyagi, Shilpa; Srivastava, Amit Kumar; Singh, Madhulika; Roy, Preeti; Singh, Richa; Shukla, Yogeshwer

Bhui, Kulpreet; Tyagi, Shilpa; Srivastava, Amit Kumar; Singh, Madhulika; Roy, Preeti; Singh, Richa; Shukla, Yogeshwer.

Affiliation

Bhui K; Proteomics Laboratory, Indian Institute of Toxicology Research, Lucknow, India.

Mol Carcinog ; 51(3): 231-43, 2012 Mar.

Article in En | MEDLINE | ID: mdl-21432909

Subject(s)

Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Bromelains/pharmacology; Carcinoma, Squamous Cell/metabolism; Cell Cycle Checkpoints/drug effects; Melanoma/metabolism; NF-kappa B/antagonists & inhibitors; Apoptosis/genetics; Bromelains/toxicity; Caspase 3/metabolism; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Cyclooxygenase 2/metabolism; Cyclooxygenase 2 Inhibitors/pharmacology; Enzyme Activation/drug effects; Glutathione/metabolism; Humans; I-kappa B Proteins/metabolism; NF-kappa B/metabolism; Phosphorylation/drug effects; Protein Transport/drug effects; Reactive Oxygen Species/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bromelains / Carcinoma, Squamous Cell / NF-kappa B / Apoptosis / Cell Cycle Checkpoints / Melanoma / Antineoplastic Agents Limits: Humans Language: En Journal: Mol Carcinog Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2012 Type: Article Affiliation country: India

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