The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration.

Randhawa, Paramjeet K; Rylova, Svetlana; Heinz, Jessica Y; Kiser, Stephanie; Fried, Joanna H; Dunworth, William P; Anderson, Amanda L; Barber, Andrew T; Chappell, John C; Roberts, David M; Bautch, Victoria L

Randhawa, Paramjeet K; Rylova, Svetlana; Heinz, Jessica Y; Kiser, Stephanie; Fried, Joanna H; Dunworth, William P; Anderson, Amanda L; Barber, Andrew T; Chappell, John C; Roberts, David M; Bautch, Victoria L.

Affiliation

Randhawa PK; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Circ Res ; 108(10): 1199-208, 2011 May 13.

Article in En | MEDLINE | ID: mdl-21474816

Subject(s)

Cell Movement/genetics; Diabetes Mellitus, Experimental/metabolism; Diabetes Mellitus, Experimental/pathology; Embryonic Stem Cells/metabolism; Endothelial Cells/metabolism; Pregnancy Complications, Cardiovascular/metabolism; Pregnancy Complications, Cardiovascular/pathology; ras Guanine Nucleotide Exchange Factors/physiology; Animals; Cells, Cultured; Diabetes Mellitus, Experimental/genetics; Embryo Culture Techniques; Embryonic Development/genetics; Embryonic Stem Cells/pathology; Endothelial Cells/pathology; Female; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnancy; Pregnancy Complications, Cardiovascular/genetics; ras Guanine Nucleotide Exchange Factors/deficiency; ras Guanine Nucleotide Exchange Factors/genetics

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnancy Complications, Cardiovascular / Cell Movement / Ras Guanine Nucleotide Exchange Factors / Endothelial Cells / Diabetes Mellitus, Experimental / Embryonic Stem Cells Type of study: Prognostic_studies Limits: Animals / Pregnancy Language: En Journal: Circ Res Year: 2011 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google