High throughput monitoring of amyloid-ß(42) assembly into soluble oligomers achieved by sensitive conformation state-dependent immunoassays.

Zhao, Wei-Qin; Toolan, Dawn; Hepler, Robert W; Wolfe, Abigail L; Yu, Yuanjiang; Price, Eric; Uebele, Victor N; Schachter, Joel B; Reynolds, Ian J; Renger, John J; McCampbell, Alexander; Ray, William J

Zhao, Wei-Qin; Toolan, Dawn; Hepler, Robert W; Wolfe, Abigail L; Yu, Yuanjiang; Price, Eric; Uebele, Victor N; Schachter, Joel B; Reynolds, Ian J; Renger, John J; McCampbell, Alexander; Ray, William J.

Affiliation

Zhao WQ; Department of Neurology, Merck Research Laboratories, West Point, PA 19486, USA. wei-qin_zhao@merck.com

J Alzheimers Dis ; 25(4): 655-69, 2011.

Article in En | MEDLINE | ID: mdl-21483096

Subject(s)

Amyloid beta-Peptides/analysis; Amyloid beta-Peptides/biosynthesis; Immunoassay/methods; Peptide Fragments/analysis; Peptide Fragments/biosynthesis; Alzheimer Disease/immunology; Animals; Dimerization; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epitopes/genetics; Hippocampus/drug effects; Hippocampus/metabolism; Humans; Light; Microscopy, Atomic Force; Neurons/metabolism; Protein Conformation; Rats; Reproducibility of Results; Scattering, Radiation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Immunoassay / Amyloid beta-Peptides Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: J Alzheimers Dis Journal subject: GERIATRIA / NEUROLOGIA Year: 2011 Type: Article Affiliation country: United States

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