Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.

Wang, Liping; Hubert, James A; Lee, Susan J; Pan, Jie; Qian, Su; Reitman, Marc L; Strack, Alison M; Weingarth, Drew T; MacNeil, Douglas J; Weber, Ann E; Edmondson, Scott D

Wang, Liping; Hubert, James A; Lee, Susan J; Pan, Jie; Qian, Su; Reitman, Marc L; Strack, Alison M; Weingarth, Drew T; MacNeil, Douglas J; Weber, Ann E; Edmondson, Scott D.

Affiliation

Wang L; Department of Medicinal Chemistry, Merck & Co. Inc., PO Box 2000, Rahway, NJ 07065, USA. liping_wang@merck.com

Bioorg Med Chem Lett ; 21(10): 2911-5, 2011 May 15.

Article in En | MEDLINE | ID: mdl-21493064

Subject(s)

Amides/chemical synthesis; Amides/pharmacology; Receptor, Cholecystokinin A/agonists; Amides/chemistry; Animals; Cells, Cultured; Heterocyclic Compounds/chemical synthesis; Heterocyclic Compounds/chemistry; Heterocyclic Compounds/pharmacology; Humans; Inhibitory Concentration 50; Mice; Molecular Structure; Protein Binding/drug effects; Pyrimidines/chemistry; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptor, Cholecystokinin A / Amides Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Type: Article Affiliation country: United States

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