A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes.

Borah, Jagat C; Mujtaba, Shiraz; Karakikes, Ioannis; Zeng, Lei; Muller, Michaela; Patel, Jigneshkumar; Moshkina, Natasha; Morohashi, Keita; Zhang, Weijia; Gerona-Navarro, Guillermo; Hajjar, Roger J; Zhou, Ming-Ming

Borah, Jagat C; Mujtaba, Shiraz; Karakikes, Ioannis; Zeng, Lei; Muller, Michaela; Patel, Jigneshkumar; Moshkina, Natasha; Morohashi, Keita; Zhang, Weijia; Gerona-Navarro, Guillermo; Hajjar, Roger J; Zhou, Ming-Ming.

Affiliation

Borah JC; Department of Structural and Chemical Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

Chem Biol ; 18(4): 531-41, 2011 Apr 22.

Article in En | MEDLINE | ID: mdl-21513889

Subject(s)

Apoptosis/drug effects; CREB-Binding Protein/metabolism; Myocytes, Cardiac/cytology; Myocytes, Cardiac/drug effects; Small Molecule Libraries/metabolism; Small Molecule Libraries/pharmacology; Animals; Azo Compounds/chemistry; Azo Compounds/metabolism; Azo Compounds/pharmacology; CREB-Binding Protein/chemistry; Cell Line, Tumor; Cytoprotection/drug effects; DNA Damage; Drug Discovery; Humans; Intracellular Space/drug effects; Intracellular Space/metabolism; Models, Molecular; Myocardial Ischemia/metabolism; Myocardial Ischemia/pathology; Myocytes, Cardiac/metabolism; Protein Binding; Protein Structure, Tertiary; Signal Transduction/drug effects; Small Molecule Libraries/chemistry; Structure-Activity Relationship; Transcription, Genetic/drug effects; Tumor Suppressor Protein p53/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Myocytes, Cardiac / CREB-Binding Protein / Small Molecule Libraries Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Chem Biol Journal subject: BIOLOGIA / BIOQUIMICA / QUIMICA Year: 2011 Type: Article Affiliation country: United States

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