Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment.

Gullbo, Joachim; Fryknäs, Mårten; Rickardson, Linda; Darcy, Padraig; Hägg, Maria; Wickström, Malin; Hassan, Sadia; Westman, Gunnar; Brnjic, Slavica; Nygren, Peter; Linder, Stig; Larsson, Rolf

Gullbo, Joachim; Fryknäs, Mårten; Rickardson, Linda; Darcy, Padraig; Hägg, Maria; Wickström, Malin; Hassan, Sadia; Westman, Gunnar; Brnjic, Slavica; Nygren, Peter; Linder, Stig; Larsson, Rolf.

Affiliation

Gullbo J; Department of Medical Sciences, Division of Clinical Pharmacology, Uppsala University Hospital, Sweden.

Biochem Pharmacol ; 82(2): 139-47, 2011 Jul 15.

Article in En | MEDLINE | ID: mdl-21531212

Subject(s)

Antineoplastic Agents/pharmacology; Drug Screening Assays, Antitumor/methods; Iron/metabolism; Ovarian Neoplasms/drug therapy; Pyridines/pharmacology; Animals; Apoptosis/drug effects; Breast Neoplasms/drug therapy; Cell Line, Tumor; Female; Hematologic Neoplasms/drug therapy; Humans; Male; Mice; Phenotype

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Pyridines / Drug Screening Assays, Antitumor / Iron / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Female / Humans / Male Language: En Journal: Biochem Pharmacol Year: 2011 Type: Article Affiliation country: Sweden

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