Interleukin-6 plays an essential role in hypoxia-inducible factor 2&#945;-induced experimental osteoarthritic cartilage destruction in mice.

Ryu, Je-Hwang; Yang, Siyoung; Shin, Youngnim; Rhee, Jinseol; Chun, Churl-Hong; Chun, Jang-Soo

Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice.

Ryu, Je-Hwang; Yang, Siyoung; Shin, Youngnim; Rhee, Jinseol; Chun, Churl-Hong; Chun, Jang-Soo.

Affiliation

Ryu JH; School of Life Science, Gwangju Institute of Science and Technology, Gwangju, Korea.

Arthritis Rheum ; 63(9): 2732-43, 2011 Sep.

Article in En | MEDLINE | ID: mdl-21590680

Subject(s)

Arthritis, Experimental/metabolism; Basic Helix-Loop-Helix Transcription Factors/metabolism; Cartilage/metabolism; Interleukin-6/metabolism; Osteoarthritis/metabolism; Animals; Arthritis, Experimental/pathology; Basic Helix-Loop-Helix Transcription Factors/genetics; Cartilage/drug effects; Cartilage/pathology; Cells, Cultured; Chondrocytes/drug effects; Chondrocytes/metabolism; Chondrocytes/pathology; Humans; Interleukin-6/genetics; Interleukin-6/pharmacology; Male; Matrix Metalloproteinase 13/genetics; Matrix Metalloproteinase 13/metabolism; Matrix Metalloproteinase 3/genetics; Matrix Metalloproteinase 3/metabolism; Mice; Mice, Transgenic; Osteoarthritis/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Arthritis, Experimental / Cartilage / Interleukin-6 / Basic Helix-Loop-Helix Transcription Factors Limits: Animals / Humans / Male Language: En Journal: Arthritis Rheum Year: 2011 Type: Article

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