Adenosine Triphosphate/metabolism; Connexins/metabolism; Lung/metabolism; Nerve Tissue Proteins/metabolism; Respiratory Mucosa/metabolism; rho GTP-Binding Proteins/metabolism; rhoA GTP-Binding Protein/metabolism; Adenosine Triphosphate/immunology; Animals; Cells, Cultured; Connexins/genetics; Connexins/immunology; Epithelial Cells/cytology; Epithelial Cells/immunology; Epithelial Cells/metabolism; Gene Knockdown Techniques; Humans; Immunity, Innate/physiology; Lung/cytology; Lung/immunology; Mice; Mice, Knockout; Mutation, Missense; Myosin Light Chains/genetics; Myosin Light Chains/immunology; Myosin Light Chains/metabolism; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/immunology; Phosphorylation/physiology; Respiratory Mucosa/cytology; Respiratory Mucosa/immunology; TRPV Cation Channels/genetics; TRPV Cation Channels/immunology; TRPV Cation Channels/metabolism; rho GTP-Binding Proteins/genetics; rho GTP-Binding Proteins/immunology; rhoA GTP-Binding Protein/genetics; rhoA GTP-Binding Protein/immunology