Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations.

Niehr, Franziska; von Euw, Erika; Attar, Narsis; Guo, Deliang; Matsunaga, Doug; Sazegar, Hooman; Ng, Charles; Glaspy, John A; Recio, Juan A; Lo, Roger S; Mischel, Paul S; Comin-Anduix, Begonya; Ribas, Antoni

Niehr, Franziska; von Euw, Erika; Attar, Narsis; Guo, Deliang; Matsunaga, Doug; Sazegar, Hooman; Ng, Charles; Glaspy, John A; Recio, Juan A; Lo, Roger S; Mischel, Paul S; Comin-Anduix, Begonya; Ribas, Antoni.

Affiliation

Niehr F; Department of Medicine, Division of Hematology/Oncology, University of California Los Angeles (UCLA), USA.

J Transl Med ; 9: 76, 2011 May 24.

Article in En | MEDLINE | ID: mdl-21609436

Subject(s)

Indoles/therapeutic use; Melanoma/drug therapy; Melanoma/genetics; Metformin/therapeutic use; Mutation/genetics; Sulfonamides/therapeutic use; Apoptosis/drug effects; Apoptosis/genetics; Blotting, Western; Cell Cycle/drug effects; Cell Cycle/genetics; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Culture Media/pharmacology; DNA Mutational Analysis; Drug Synergism; Flow Cytometry; Glucose/pharmacology; Humans; Indoles/pharmacology; Metformin/pharmacology; Phosphorylation/drug effects; Phosphothreonine/metabolism; Proto-Oncogene Proteins B-raf/genetics; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction/drug effects; Signal Transduction/genetics; Sulfonamides/pharmacology; Time Factors; Vemurafenib

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Indoles / Melanoma / Metformin / Mutation Limits: Humans Language: En Journal: J Transl Med Year: 2011 Type: Article Affiliation country: United States

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