Cellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments.

Nikbakht, Neda; Migone, Thi-Sau; Ward, Chris P; Manser, Tim

Nikbakht, Neda; Migone, Thi-Sau; Ward, Chris P; Manser, Tim.

Affiliation

Nikbakht N; Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

J Immunol ; 187(1): 37-46, 2011 Jul 01.

Article in En | MEDLINE | ID: mdl-21632709

Subject(s)

Autoantigens/immunology; B-Cell Activating Factor/physiology; B-Lymphocyte Subsets/immunology; Cell Differentiation/immunology; Clonal Anergy/immunology; Lymphopenia/immunology; Animals; B-Cell Activating Factor/metabolism; B-Lymphocyte Subsets/pathology; Cell Differentiation/genetics; Cells, Cultured; Clonal Anergy/genetics; Gene Knock-In Techniques; Lymphocyte Count; Lymphopenia/genetics; Lymphopenia/pathology; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mice, Transgenic; Radiation Chimera; Recombinant Proteins/metabolism; Recombinant Proteins/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoantigens / Cell Differentiation / B-Lymphocyte Subsets / Clonal Anergy / B-Cell Activating Factor / Lymphopenia Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Immunol Year: 2011 Type: Article Affiliation country: United States

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