The base component of 3'-azido-2',3'-dideoxynucleosides influences resistance mutations selected in HIV-1 reverse transcriptase.

Meteer, Jeffrey D; Koontz, Dianna; Asif, Ghazia; Zhang, Hong-wang; Detorio, Mervi; Solomon, Sarah; Coats, Steven J; Sluis-Cremer, Nicolas; Schinazi, Raymond F; Mellors, John W

Meteer, Jeffrey D; Koontz, Dianna; Asif, Ghazia; Zhang, Hong-wang; Detorio, Mervi; Solomon, Sarah; Coats, Steven J; Sluis-Cremer, Nicolas; Schinazi, Raymond F; Mellors, John W.

Affiliation

Meteer JD; University of Pittsburgh School of Medicine, Department of Medicine, Division of Infectious Diseases, Pittsburgh, PA 15261, USA.

Antimicrob Agents Chemother ; 55(8): 3758-64, 2011 Aug.

Article in En | MEDLINE | ID: mdl-21646480

Subject(s)

Anti-HIV Agents/pharmacology; Dideoxynucleosides/pharmacology; HIV Reverse Transcriptase/antagonists & inhibitors; HIV-1/drug effects; Reverse Transcriptase Inhibitors/pharmacology; Azides/pharmacology; Base Sequence; Dideoxyadenosine/analogs & derivatives; Dideoxyadenosine/pharmacology; Drug Resistance, Viral; HIV Reverse Transcriptase/metabolism; HIV-1/genetics; Mutagenesis, Site-Directed; Sequence Analysis, RNA; Zalcitabine/analogs & derivatives; Zalcitabine/pharmacology; Zidovudine/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dideoxynucleosides / HIV-1 / Reverse Transcriptase Inhibitors / Anti-HIV Agents / HIV Reverse Transcriptase Type of study: Prognostic_studies Language: En Journal: Antimicrob Agents Chemother Year: 2011 Type: Article Affiliation country: United States

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