Synthesis and antiviral activity of monofluoro and difluoro analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1).

Martin, J A; Bushnell, D J; Duncan, I B; Dunsdon, S J; Hall, M J; Machin, P J; Merrett, J H; Parkes, K E; Roberts, N A; Thomas, G J

Martin, J A; Bushnell, D J; Duncan, I B; Dunsdon, S J; Hall, M J; Machin, P J; Merrett, J H; Parkes, K E; Roberts, N A; Thomas, G J.

Affiliation

Martin JA; Research Division, Roche Products Limited, Welwyn Garden City, Hertfordshire, England.

J Med Chem ; 33(8): 2137-45, 1990 Aug.

Article in En | MEDLINE | ID: mdl-2165161

Subject(s)

Antiviral Agents/pharmacology; Deoxyribonucleosides/pharmacology; Fluorine; HIV-1/drug effects; Pyrimidine Nucleosides/pharmacology; Antiviral Agents/chemical synthesis; Cell Line; Cell Survival/drug effects; Chemical Phenomena; Chemistry; Deoxyribonucleosides/chemical synthesis; Dideoxynucleosides/chemical synthesis; Dideoxynucleosides/pharmacology; Humans; Lymphocytes/drug effects; Molecular Structure; Pyrimidine Nucleosides/chemical synthesis; Structure-Activity Relationship; Zalcitabine/analogs & derivatives; Zalcitabine/chemical synthesis; Zalcitabine/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Pyrimidine Nucleosides / HIV-1 / Deoxyribonucleosides / Fluorine Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1990 Type: Article Affiliation country: United kingdom

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