Mediators involved in retinopathy of prematurity and emerging therapeutic targets.
Early Hum Dev
; 87(10): 683-90, 2011 Oct.
Article
in En
| MEDLINE
| ID: mdl-21700404
ABSTRACT
Retinopathy of prematurity (ROP) is a potentially blinding disease of premature infants and despite timely treatment some infants develop retinal detachment and sight loss. Current treatment utilises laser therapy which causes destruction of treated retinal tissue resulting in field loss. There is considerable research work ongoing on neovascular eye disease which is likely to result in antiangiogenic approaches that will arrest the development of ROP by specifically targeting the involved molecular mediators. Some of these new therapeutic interventions have entered clinical trials. This article reviews new information available on the molecular pathogenesis of ROP which may result in novel treatments for ROP; it does not discuss the well-known role of oxygen in the development of ROP.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Retinopathy of Prematurity
/
Insulin-Like Growth Factor I
/
Vascular Endothelial Growth Factor A
Limits:
Humans
/
Newborn
Language:
En
Journal:
Early Hum Dev
Year:
2011
Type:
Article
Affiliation country:
United kingdom