Pharmacodynamic effects on biochemical markers of bone turnover and pharmacokinetics of the cathepsin K inhibitor, ONO-5334, in an ascending multiple-dose, phase 1 study.

Nagase, Shinichi; Ohyama, Michiyo; Hashimoto, Yoshitaka; Small, Maria; Kuwayama, Tomohiro; Deacon, Steve

Nagase, Shinichi; Ohyama, Michiyo; Hashimoto, Yoshitaka; Small, Maria; Kuwayama, Tomohiro; Deacon, Steve.

Affiliation

Nagase S; Clinical Development, ONO PHARMA UK Ltd., 11th Floor, Marble Arch Tower, 55 Bryanston Street, London W1H 7AA, UK. s-nagase@ono-uk.co.uk

J Clin Pharmacol ; 52(3): 306-18, 2012 Mar.

Article in En | MEDLINE | ID: mdl-21719717

Subject(s)

Bone Density Conservation Agents/pharmacology; Bone Density Conservation Agents/pharmacokinetics; Bone Density/drug effects; Osteoporosis, Postmenopausal/prevention & control; Thiazolidines/pharmacology; Thiazolidines/pharmacokinetics; Area Under Curve; Biomarkers/blood; Bone Density Conservation Agents/administration & dosage; Bone Density Conservation Agents/adverse effects; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Half-Life; Humans; Middle Aged; Thiazolidines/administration & dosage; Thiazolidines/adverse effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Density / Osteoporosis, Postmenopausal / Bone Density Conservation Agents / Thiazolidines Type of study: Clinical_trials / Prognostic_studies Limits: Female / Humans / Middle aged Language: En Journal: J Clin Pharmacol Year: 2012 Type: Article Affiliation country: United kingdom

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