The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice.

Courey, Anthony J; Horowitz, Jeffrey C; Kim, Kevin K; Koh, Timothy J; Novak, Margaret L; Subbotina, Natalya; Warnock, Mark; Xue, Bing; Cunningham, Andrew K; Lin, Yujing; Goldklang, Monica P; Simon, Richard H; Lawrence, Daniel A; Sisson, Thomas H

Courey, Anthony J; Horowitz, Jeffrey C; Kim, Kevin K; Koh, Timothy J; Novak, Margaret L; Subbotina, Natalya; Warnock, Mark; Xue, Bing; Cunningham, Andrew K; Lin, Yujing; Goldklang, Monica P; Simon, Richard H; Lawrence, Daniel A; Sisson, Thomas H.

Affiliation

Courey AJ; Division of Pulmonary and Critical Care Medicine. Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

Blood ; 118(8): 2313-21, 2011 Aug 25.

Article in En | MEDLINE | ID: mdl-21734232

Subject(s)

Pulmonary Fibrosis/etiology; Pulmonary Fibrosis/metabolism; Serpin E2/metabolism; Vitronectin/metabolism; Animals; Bleomycin/administration & dosage; Bleomycin/toxicity; Bronchoalveolar Lavage Fluid/chemistry; Collagen/metabolism; Disease Models, Animal; Humans; Hydroxyproline/metabolism; Lung/drug effects; Lung/metabolism; Lung/pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mutant Proteins/genetics; Mutant Proteins/metabolism; Plasminogen Activator Inhibitor 1/genetics; Plasminogen Activator Inhibitor 1/metabolism; Protein Binding; Pulmonary Fibrosis/pathology; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Serpin E2/blood; Serpin E2/deficiency; Serpin E2/genetics; Vitronectin/blood

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Fibrosis / Vitronectin / Serpin E2 Limits: Animals / Humans Language: En Journal: Blood Year: 2011 Type: Article Affiliation country: United States

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