Tamsulosin shows a higher unbound drug fraction in human prostate than in plasma: a basis for uroselectivity?

Korstanje, Cees; Krauwinkel, Walter; van Doesum-Wolters, Francisca L C

Korstanje, Cees; Krauwinkel, Walter; van Doesum-Wolters, Francisca L C.

Affiliation

Korstanje C; Translational & Development Pharmacology Department, Astellas Pharma Europe BV, Elisabethhof 1, 2353 EW Leiderdorp, the Netherlands. cees.korstanje@eu.astellas.com

Br J Clin Pharmacol ; 72(2): 218-25, 2011 Aug.

Article in En | MEDLINE | ID: mdl-21745239

Subject(s)

Adrenergic alpha-1 Receptor Antagonists/pharmacokinetics; Prostatic Hyperplasia/metabolism; Sulfonamides/pharmacokinetics; Aged; Aged, 80 and over; Blood Proteins/metabolism; Humans; Male; Middle Aged; Orosomucoid/metabolism; Prostate/metabolism; Protein Binding/drug effects; Tamsulosin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Hyperplasia / Sulfonamides / Adrenergic alpha-1 Receptor Antagonists Type of study: Clinical_trials Limits: Aged / Aged80 / Humans / Male / Middle aged Language: En Journal: Br J Clin Pharmacol Year: 2011 Type: Article Affiliation country: Netherlands

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