Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit Î¶ 2 renders tumor cells dependent on its paralogous gene COPZ1.

Shtutman, Michael; Baig, Mirza; Levina, Elina; Hurteau, Gregory; Lim, Chang-Uk; Broude, Eugenia; Nikiforov, Mikhail; Harkins, Timothy T; Carmack, C Steven; Ding, Ye; Wieland, Felix; Buttyan, Ralph; Roninson, Igor B

Shtutman, Michael; Baig, Mirza; Levina, Elina; Hurteau, Gregory; Lim, Chang-Uk; Broude, Eugenia; Nikiforov, Mikhail; Harkins, Timothy T; Carmack, C Steven; Ding, Ye; Wieland, Felix; Buttyan, Ralph; Roninson, Igor B.

Affiliation

Shtutman M; Cancer Center, Ordway Research Institute, Albany, NY 12208, USA. shtutmanm@sccp.sc.edu

Proc Natl Acad Sci U S A ; 108(30): 12449-54, 2011 Jul 26.

Article in En | MEDLINE | ID: mdl-21746916

Subject(s)

Coatomer Protein/genetics; Neoplasms/genetics; Apoptosis/genetics; Autophagy/genetics; Base Sequence; Cell Line, Tumor; DNA, Neoplasm/genetics; Female; Gene Knockdown Techniques; Gene Silencing; Golgi Apparatus/genetics; Golgi Apparatus/pathology; Humans; Male; MicroRNAs/genetics; Neoplasms/pathology; Protein Isoforms/genetics; RNA, Neoplasm/genetics; RNA, Small Interfering/genetics; Suppression, Genetic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Coatomer Protein / Neoplasms Limits: Female / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2011 Type: Article Affiliation country: United States

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